Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

Virtually all SARS-CoV-2 vaccines currently in clinical testing are stored in a refrigerated or frozen state prior to use. This is a major impediment to deployment in resource-poor settings. Furthermore, several of them use viral vectors or mRNA. In contrast to protein subunit vaccines, there is lim...

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Vydáno v:J Biol Chem
Hlavní autoři: Malladi, Sameer Kumar, Singh, Randhir, Pandey, Suman, Gayathri, Savitha, Kanjo, Kawkab, Ahmed, Shahbaz, Khan, Mohammad Suhail, Kalita, Parismita, Girish, Nidhi, Upadhyaya, Aditya, Reddy, Poorvi, Pramanick, Ishika, Bhasin, Munmun, Mani, Shailendra, Bhattacharyya, Sankar, Joseph, Jeswin, Thankamani, Karthika, Raj, V. Stalin, Dutta, Somnath, Singh, Ramandeep, Nadig, Gautham, Varadarajan, Raghavan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7832000/
https://ncbi.nlm.nih.gov/pubmed/33154165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016284
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