Functional and genomic characterization of patient‐derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma

Resistance to the mechanistic target of rapamycin (mTOR) inhibitors, which are a standard treatment for advanced clear cell renal cell carcinoma (ccRCC), eventually develops in most cases. In this study, we established a patient‐derived xenograft (PDX) model which acquired resistance to the mTOR inh...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Sakamoto, Hiromasa, Yamasaki, Toshinari, Sumiyoshi, Takayuki, Takeda, Masashi, Shibasaki, Noboru, Utsunomiya, Noriaki, Arakaki, Ryuichiro, Akamatsu, Shusuke, Kobayashi, Takashi, Inoue, Takahiro, Kamba, Tomomi, Nakamura, Eijiro, Ogawa, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Clinical Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826464/
https://ncbi.nlm.nih.gov/pubmed/33107222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3578
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