A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity

BACKGROUND: Aberrant activation of the Hedgehog pathway drives tumorigenesis of many cancers, including glioblastoma. However, the sensitization mechanism of the G protein-coupled-like receptor smoothened (SMO), a key component of Hedgehog signaling, remains largely unknown. RESULTS: In this study,...

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Vydáno v:Genome Biol
Hlavní autoři: Wu, Xujia, Xiao, Songhua, Zhang, Maolei, Yang, Lixuan, Zhong, Jian, Li, Bo, Li, Fanying, Xia, Xin, Li, Xixi, Zhou, Huangkai, Liu, Dawei, Huang, Nunu, Yang, Xuesong, Xiao, Feizhe, Zhang, Nu
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807754/
https://ncbi.nlm.nih.gov/pubmed/33446260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02250-6
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