Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatment. The discovery of CFTR modulators has shown efficacy in c...

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Vydáno v:Sci Rep
Hlavní autoři: Nguyen, Jenny P., Bianca, Matthew, Huff, Ryan D., Tiessen, Nicholas, Inman, Mark D., Hirota, Jeremy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807051/
https://ncbi.nlm.nih.gov/pubmed/33441643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79555-w
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