Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts

BACKGROUND: Antitumor immunity is highly heterogeneous between individuals; however, underlying mechanisms remain elusive, despite their potential to improve personalized cancer immunotherapy. Head and neck squamous cell carcinomas (HNSCCs) vary significantly in immune infiltration and therapeutic r...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Woolaver, Rachel A, Wang, Xiaoguang, Krinsky, Alexandra L, Waschke, Brittany C, Chen, Samantha M Y, Popolizio, Vince, Nicklawsky, Andrew G, Gao, Dexiang, Chen, Zhangguo, Jimeno, Antonio, Wang, Xiao-Jing, Wang, Jing Hong
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797305/
https://ncbi.nlm.nih.gov/pubmed/33414263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001615
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