Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb, and DNA methylation

The COMPASS protein family catalyzes histone H3 lysine 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates H3K4 on many developmental genes and bivalent clusters. To understand MLL2-dependent transcriptional regulation, we performed a CRISPR-bas...

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Publicat a:Nat Genet
Autors principals: Douillet, Delphine, Sze, Christie C, Ryan, Caila, Piunti, Andrea, Shah, Avani P, Ugarenko, Michal, Marshall, Stacy A, Rendleman, Emily J, Zha, Didi, Helmin, Kathryn A, Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A, Singer, Benjamin D, Bartom, Elizabeth, Smith, Edwin R, Shilatifard, Ali
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790509/
https://ncbi.nlm.nih.gov/pubmed/32393859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0618-1
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