Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb, and DNA methylation

The COMPASS protein family catalyzes histone H3 lysine 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates H3K4 on many developmental genes and bivalent clusters. To understand MLL2-dependent transcriptional regulation, we performed a CRISPR-bas...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Genet
Main Authors: Douillet, Delphine, Sze, Christie C, Ryan, Caila, Piunti, Andrea, Shah, Avani P, Ugarenko, Michal, Marshall, Stacy A, Rendleman, Emily J, Zha, Didi, Helmin, Kathryn A, Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A, Singer, Benjamin D, Bartom, Elizabeth, Smith, Edwin R, Shilatifard, Ali
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790509/
https://ncbi.nlm.nih.gov/pubmed/32393859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0618-1
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker