Pharmacological blockade of TNFα prevents sarcopenia and prolongs survival in aging mice

Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectio...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Sciorati, Clara, Gamberale, Riccardo, Monno, Antonella, Citterio, Lorena, Lanzani, Chiara, De Lorenzo, Rebecca, Ramirez, Giuseppe A., Esposito, Antonio, Manunta, Paolo, Manfredi, Angelo A., Rovere-Querini, Patrizia
Format: Artigo
Language:Inglês
Published: Impact Journals 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762456/
https://ncbi.nlm.nih.gov/pubmed/33260150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202200
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