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Synthesis and in Silico Modelling of the Potential Dual Mechanistic Activity of Small Cationic Peptides Potentiating the Antibiotic Novobiocin against Susceptible and Multi-Drug Resistant Escherichia coli

Cationic antimicrobial peptides have attracted interest, both as antimicrobial agents and for their ability to increase cell permeability to potentiate other antibiotics. However, toxicity to mammalian cells and complexity have hindered development for clinical use. We present the design and synthes...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Passarini, Ilaria, de Resende, Pedro Ernesto, Soares, Sarah, Tahmasi, Tadeh, Stapleton, Paul, Malkinson, John, Zloh, Mire, Rossiter, Sharon
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730182/
https://ncbi.nlm.nih.gov/pubmed/33266278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239134
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