Synthesis and in Silico Modelling of the Potential Dual Mechanistic Activity of Small Cationic Peptides Potentiating the Antibiotic Novobiocin against Susceptible and Multi-Drug Resistant Escherichia coli

Cationic antimicrobial peptides have attracted interest, both as antimicrobial agents and for their ability to increase cell permeability to potentiate other antibiotics. However, toxicity to mammalian cells and complexity have hindered development for clinical use. We present the design and synthes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Mol Sci
Prif Awduron: Passarini, Ilaria, de Resende, Pedro Ernesto, Soares, Sarah, Tahmasi, Tadeh, Stapleton, Paul, Malkinson, John, Zloh, Mire, Rossiter, Sharon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730182/
https://ncbi.nlm.nih.gov/pubmed/33266278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239134
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