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Integrating expert opinions with clinical trial data to analyse low-powered subgroup analyses: a Bayesian analysis of the VeRDiCT trial

BACKGROUND: Typically, subgroup analyses in clinical trials are conducted by comparing the intervention effect in each subgroup by means of an interaction test. However, trials are rarely, if ever, adequately powered for interaction tests, so clinically important interactions may go undetected. We d...

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Principais autores: Thirard, Russell, Ascione, Raimondo, Blazeby, Jane M., Rogers, Chris A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727208/
https://ncbi.nlm.nih.gov/pubmed/33302878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-020-01178-6
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