Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells

A major risk factor promoting tumor development is chronic inflammation and the use of nonsteroidal anti-inflammatory drugs (NSAID), including ibuprofen, can decrease the risk of developing various types of cancer, including colorectal cancer (CRC). Although the molecular mechanism behind the antitu...

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Udgivet i:Oncotarget
Main Authors: Gonçalves, Vânia, Henriques, Andreia F.A., Matos, Paulo, Jordan, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720772/
https://ncbi.nlm.nih.gov/pubmed/33315986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27816
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