An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling

Agonist binding promotes activation of G protein-coupled receptors (GPCRs) and association of active receptors with G protein heterotrimers. The resulting active-state ternary complex is the basis for conventional stimulus-response coupling. Although GPCRs can also associate with G proteins before a...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Jang, Wonjo, Adams, C. Elizabeth, Liu, Heng, Zhang, Cheng, Levy, Finn Olav, Andressen, Kjetil Wessel, Lambert, Nevin A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720138/
https://ncbi.nlm.nih.gov/pubmed/33199589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010801117
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