Paxilline Prevents the Onset of Myotonic Stiffness in Pharmacologically Induced Myotonia: A Preclinical Investigation

Reduced Cl(−) conductance causes inhibited muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. This represents the pathomechanism of myotonia congenita. Due to the prevailing data suggesting that an increased potassium level is a main contributor, we stud...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Hoppe, Kerstin, Sartorius, Tina, Chaiklieng, Sunisa, Wietzorrek, Georg, Ruth, Peter, Jurkat-Rott, Karin, Wearing, Scott, Lehmann-Horn, Frank, Klingler, Werner
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719791/
https://ncbi.nlm.nih.gov/pubmed/33329012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.533946
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