Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (CAS); a hydrocarbon tether with variable leng...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Ahuja-Casarín, Ana I., Merino-Montiel, Penélope, Vega-Baez, José Luis, Montiel-Smith, Sara, Fernandes, Miguel X., Lagunes, Irene, Maya, Inés, Padrón, José M., López, Óscar, Fernández-Bolaños, José G.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717699/
https://ncbi.nlm.nih.gov/pubmed/33228403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1847101
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