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Development of Site-Specific PEGylated Granulocyte Colony Stimulating Factor With Prolonged Biological Activity
Currently, amino-terminal PEGylated human granulocyte colony stimulating factor (huG-CSF) is used to prevent and treat neutropenia. Although huG-CSF has been used as a drug for more than 20 years, it has three significant drawbacks: (i) it relies on PEG aldehyde for PEGylation of the alpha-amino gro...
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| Udgivet i: | Front Bioeng Biotechnol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7710547/ https://ncbi.nlm.nih.gov/pubmed/33330413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.572077 |
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