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Valproic Acid Thermally Destabilizes and Inhibits SpyCas9 Activity

The clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system plays an important role in prokaryotic adaptive immunity. Due to its capacity for sequence-specific gene editing, CRISPR-Cas9 has become one of the most important tools widely used for genome editing in molecular biote...

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Detalhes bibliográficos
Publicado no:Mol Ther
Autor principal: Cheng, Xinlai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704752/
https://ncbi.nlm.nih.gov/pubmed/32882179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.08.014
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