IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

Occurrence of Colorectal cancer (CRC) is relevant with gut microbiota. However, role of IRF3, a key signaling mediator in innate immune sensing, has been barely investigated in CRC. Here, we unexpectedly found that the IRF3 deficient mice are hyper-susceptible to the development of intestinal tumor...

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Publicat a:Nat Commun
Autors principals: Tian, Miao, Wang, Xiumei, Sun, Jihong, Lin, Wenlong, Chen, Lumin, Liu, Shengduo, Wu, Ximei, Shi, Liyun, Xu, Pinglong, Cai, Xiujun, Wang, Xiaojian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666182/
https://ncbi.nlm.nih.gov/pubmed/33188184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19627-7
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