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Phosphoramidate derivates as controlled-release prodrugs of l-Dopa
l-Dopa has continued to be a mainstay in the symptomatic treatment of Parkinson’s disease (PD). However, extensive peripheral metabolism, a short systemic circulation half-life and development of motor complications called dyskinesia prevents its long-term utilization as a PD therapeutic. Herein, we...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7654512/ https://ncbi.nlm.nih.gov/pubmed/31400939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.08.005 |
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