Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells

Primary toxicity targets of alcohol and its metabolites in the pancreas are cellular energetics and endoplasmic reticulum (ER). Therefore, the role of AMP-Activated Protein Kinase (AMPKα) in amelioration of ethanol (EtOH)-induced pancreatic acinar cell injury including ER/oxidative stress, inflammat...

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Publicado no:Biochem Pharmacol
Main Authors: Srinivasan, Mukund P, Bhopale, Kamlesh K, Caracheo, Anna A, Amer, Samir M, Khan, Shamis, Kaphalia, Lata, Loganathan, Gopalakrishnan, Balamurugan, Appakalai N, Kaphalia, Bhupendra S
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651864/
https://ncbi.nlm.nih.gov/pubmed/32717227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114174
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