Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells

Primary toxicity targets of alcohol and its metabolites in the pancreas are cellular energetics and endoplasmic reticulum (ER). Therefore, the role of AMP-Activated Protein Kinase (AMPKα) in amelioration of ethanol (EtOH)-induced pancreatic acinar cell injury including ER/oxidative stress, inflammat...

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Publicat a:Biochem Pharmacol
Autors principals: Srinivasan, Mukund P, Bhopale, Kamlesh K, Caracheo, Anna A, Amer, Samir M, Khan, Shamis, Kaphalia, Lata, Loganathan, Gopalakrishnan, Balamurugan, Appakalai N, Kaphalia, Bhupendra S
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651864/
https://ncbi.nlm.nih.gov/pubmed/32717227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114174
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