DNMT3B PWWP mutations cause hypermethylation of heterochromatin

The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved by the de novo DNA methyltransferases DNMT3A and DNMT3B. DNMT3B localises to H3K36me3 at actively transcribing gene bodies via its PWWP domain. It also functions at heterochromatin through an unk...

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Udgivet i:EMBO Rep
Main Authors: Taglini, Francesca, Kafetzopoulos, Ioannis, Rolls, Willow, Musialik, Kamila Irena, Lee, Heng Yang, Zhang, Yujie, Marenda, Mattia, Kerr, Lyndsay, Finan, Hannah, Rubio-Ramon, Cristina, Gautier, Philippe, Wapenaar, Hannah, Kumar, Dhananjay, Davidson-Smith, Hazel, Wills, Jimi, Murphy, Laura C, Wheeler, Ann, Wilson, Marcus D, Sproul, Duncan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2024
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615734/
https://ncbi.nlm.nih.gov/pubmed/38291337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s44319-024-00061-5
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