Different eGFR Decline Thresholds and Renal Effects of Canagliflozin: Data from the CANVAS Program

BACKGROUND: Traditionally, clinical trials evaluating effects of a new therapy with creatinine-based renal end points use doubling of serum creatinine (equivalent to a 57% eGFR reduction), requiring large sample sizes. METHODS: To assess whether eGFR declines <57% could detect canagliflozin’s eff...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Oshima, Megumi, Neal, Bruce, Toyama, Tadashi, Ohkuma, Toshiaki, Li, Qiang, de Zeeuw, Dick, Heerspink, Hiddo J.L., Mahaffey, Kenneth W., Fulcher, Gregory, Canovatchel, William, Matthews, David R., Perkovic, Vlado
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609006/
https://ncbi.nlm.nih.gov/pubmed/32694216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019121312
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