Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction

Mechanical cues activate cardiac fibroblasts and induce differentiation into myofibroblasts, which are key steps for development of cardiac fibrosis. In vitro, the high stiffness of plastic culturing conditions will also induce these changes. It is therefore challenging to study resting cardiac fibr...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Gilles, George, McCulloch, Andrew D., Brakebusch, Cord H., Herum, Kate M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588109/
https://ncbi.nlm.nih.gov/pubmed/33104742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241390
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items