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Secreted factors from pro-inflammatory macrophages promote an osteoblast-like phenotype in valvular interstitial cells

OBJECTIVE: Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic valve stenosis (AVS) progression, which further promotes fibrosis or even differentiate into osteoblast-like cells that can lead to calcification of valve tissue. Inflammation is a hallmark of AVS, so we...

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Detaylı Bibliyografya
Yayımlandı:Arterioscler Thromb Vasc Biol
Asıl Yazarlar: Grim, Joseph C., Aguado, Brian A., Vogt, Brandon J., Batan, Dilara, Andrichik, Cassidy L., Schroeder, Megan E., Gonzalez-Rodriguez, Andrea, Yavitt, F. Max, Weiss, Robert M., Anseth, Kristi S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578003/
https://ncbi.nlm.nih.gov/pubmed/32938214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315261
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