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Secreted factors from pro-inflammatory macrophages promote an osteoblast-like phenotype in valvular interstitial cells
OBJECTIVE: Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic valve stenosis (AVS) progression, which further promotes fibrosis or even differentiate into osteoblast-like cells that can lead to calcification of valve tissue. Inflammation is a hallmark of AVS, so we...
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| Publicado en: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7578003/ https://ncbi.nlm.nih.gov/pubmed/32938214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315261 |
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