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The succinct synthesis of AT13387, a clinically relevant Hsp90 inhibitor
AT13387 is an orally bioavailable clinical candidate developed to inhibit theheat shock protein 90 (Hsp90). This article describes a modified synthetic route for the multi-gram production of AT13387 in 46% overall yield. The modified synthetic route is short, avoids stringent reaction conditions and...
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| Publicado no: | Synth Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7577423/ https://ncbi.nlm.nih.gov/pubmed/33093687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00397911.2019.1602654 |
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