Atypical TRAV1-2(−) T cell receptor recognition of the antigen-presenting molecule MR1

MR1 presents vitamin B–related metabolites to mucosal associated invariant T (MAIT) cells, which are characterized, in part, by the TRAV1-2(+) αβ T cell receptor (TCR). In addition, a more diverse TRAV1-2(−) MR1-restricted T cell repertoire exists that can possess altered specificity for MR1 antigen...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Awad, Wael, Meermeier, Erin W., Sandoval-Romero, Maria L., Le Nours, Jérôme, Worley, Aneta H., Null, Megan D., Liu, Ligong, McCluskey, James, Fairlie, David P., Lewinsohn, David M., Rossjohn, Jamie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573270/
https://ncbi.nlm.nih.gov/pubmed/32817339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015292
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