The Role of PARP1 in Monocyte and Macrophage Commitment and Specification: Future Perspectives and Limitations for the Treatment of Monocyte and Macrophage Relevant Diseases with PARP Inhibitors

Modulation of PARP1 expression, changes in its enzymatic activity, post-translational modifications, and inflammasome-dependent cleavage play an important role in the development of monocytes and numerous subtypes of highly specialized macrophages. Transcription of PARP1 is governed by the prolifera...

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Udgivet i:Cells
Main Authors: Sobczak, Maciej, Zyma, Marharyta, Robaszkiewicz, Agnieszka
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565932/
https://ncbi.nlm.nih.gov/pubmed/32900001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9092040
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