Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletio...

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Udgivet i:Nat Commun
Main Authors: Jiang, Huimin, Zhou, Chen, Zhang, Zhen, Wang, Qiong, Wei, Huimin, Shi, Wen, Li, Jianjun, Wang, Zhaoyang, Ou, Yang, Wang, Wenhao, Wang, Hang, Zhang, Quansheng, Sun, Wei, Sun, Peiqing, Yang, Shuang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552407/
https://ncbi.nlm.nih.gov/pubmed/33046710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18860-4
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