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A Selenourea-Thiourea Brønsted Acid Catalyst Facilitates Asymmetric Conjugate Additions of Amines to α,β-Unsaturated Esters

β-Amino esters are obtained with high levels of enantioselectivity via the conjugate addition of cyclic amines to unactivated α,β-unsaturated esters. A related strategy enables the kinetic resolution of racemic cyclic 2-arylamines, using benzyl acrylate as the resolving agent. Reactions are facilita...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Lin, Yingfu, Hirschi, William J., Kunadia, Anuj, Paul, Anirudra, Ghiviriga, Ion, Abboud, Khalil A., Karugu, Rachael W., Vetticatt, Mathew J., Hirschi, Jennifer S., Seidel, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533150/
https://ncbi.nlm.nih.gov/pubmed/32118419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b12457
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