An Adaptive Bayesian Design for Personalized Dosing in a Cancer Prevention Trial

INTRODUCTION: In biomarker-driven clinical trials, translational strategies typically involve moving findings from animal experiments to human trials. Typically, the translation is static, using a fixed model derived from animal experiments for the duration of the trial. But Bayesian designs, capabl...

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Udgivet i:Am J Prev Med
Main Authors: Sen, Ananda, Zhao, Lili, Djuric, Zora, Turgeon, D. Kim, Ruffin, Mack T., Smith, William L., Brenner, Dean E., Normolle, Daniel P.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531353/
https://ncbi.nlm.nih.gov/pubmed/32951684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amepre.2020.04.023
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