Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility

Because isoenzymes of the experimentally and therapeutically extremely relevant sirtuin family show high similarity, addressing the unique selectivity pocket of sirtuin 2 is a promising strategy towards selective inhibitors. An unrelated approach towards selective inhibition of isoenzymes with varie...

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Vydáno v:ChemMedChem
Hlavní autoři: Grathwol, Christoph W., Wössner, Nathalie, Behnisch‐Cornwell, Steven, Schulig, Lukas, Zhang, Lin, Einsle, Oliver, Jung, Manfred, Link, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496931/
https://ncbi.nlm.nih.gov/pubmed/32314517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000148
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