Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation

Glenzocimab (ACT017) is a humanized monoclonal antigen‐binding fragment (Fab) directed against the human platelet glycoprotein VI, a key receptor for collagen and fibrin that plays a major role in thrombus growth and stability. Glenzocimab is being developed as an antiplatelet agent to treat the acu...

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Vydáno v:J Clin Pharmacol
Hlavní autoři: Renaud, Lionel, Lebozec, Kristell, Voors‐Pette, Christine, Dogterom, Peter, Billiald, Philippe, Jandrot Perrus, Martine, Pletan, Yannick, Machacek, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Non Covid Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496554/
https://ncbi.nlm.nih.gov/pubmed/32500636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1616
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