Discovery and characterization of the antimetabolite action of thioacetamide-linked 1,2,3-triazoles as disruptors of cysteine biosynthesis in Gram-negative bacteria

Increasing rates of drug-resistant Gram-negative (GN) infections, combined with a lack of new GN-effective antibiotic classes, is driving the need for the discovery of new agents. Bacterial metabolism represents an underutilized mechanism of action in current antimicrobial therapies. Therefore, we s...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Wallace, Miranda J., Dharuman, Suresh, Fernando, Dinesh M., Reeve, Stephanie M., Gee, Clifford T., Yao, Jiangwei, Griffith, Elizabeth C., Phelps, Gregory A., Wright, William C., Elmore, John M., Lee, Robin B., Chen, Taosheng, Lee, Richard E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477787/
https://ncbi.nlm.nih.gov/pubmed/31887254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00406
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