Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies

A novel series of pyrazole analogues including hydrazones, pyrazolo[4,3-c]-pyridazines, pyrazolo[3,4-e][1,2,4]triazine and pyrazolo[3,4-d][1,2,3]triazoles was designed, synthesised and screened for their in vitro antimicrobial and DHFR inhibition activity. Compounds bearing benzenesulphonamide moiet...

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Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Othman, Ismail M. M., Gad-Elkareem, Mohamed A. M., Amr, Abd El-Galil E., Al-Omar, Mohamed A., Nossier, Eman S., Elsayed, Elsayed A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470138/
https://ncbi.nlm.nih.gov/pubmed/32668994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1791842
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