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Specific Binding of snoRNAs to PARP-1 Promotes NAD(+)-Dependent Catalytic Activation
Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant and ubiquitous nuclear enzyme that catalyzes the transfer of ADP-ribose (ADPR) from donor NAD(+) molecules to specific amino acids on substrate proteins. The catalytic activity of PARP-1 has long been known to be allosterically stimulated by the...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7458537/ https://ncbi.nlm.nih.gov/pubmed/32293172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00100 |
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