Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics

Glioblastoma (GBM) is the most aggressive malignant primary brain tumour with a median overall survival of 15 months. To treat GBM, patients currently undergo a surgical resection followed by exposure to radiotherapy and concurrent and adjuvant temozolomide (TMZ) chemotherapy. However, this protocol...

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Dettagli Bibliografici
Pubblicato in:R Soc Open Sci
Autori principali: Lasri, Ayoub, Juric, Viktorija, Verreault, Maité, Bielle, Franck, Idbaih, Ahmed, Kel, Alexander, Murphy, Brona, Sturrock, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society 2020
Soggetti:
Mathematics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428254/
https://ncbi.nlm.nih.gov/pubmed/32874597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.191243
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