An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases

Sirtuin 2 (Sirt2), an NAD(+)-dependent protein deacetylase, deacetylates tubulin, AKT, and other proteins. Previously, we showed that Sirt2 isoform 1 (Sirt2.1) increased replication of hepatitis B virus (HBV). Here, we show that HBV replication upregulates the expression of Sirt2 primary and alterna...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Piracha, Zahra Zahid, Saeed, Umar, Kim, Jumi, Kwon, Hyeonjoong, Chwae, Yong-Joon, Lee, Hyun Woong, Lim, Jin Hong, Park, Sun, Shin, Ho-Joon, Kim, Kyongmin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394897/
https://ncbi.nlm.nih.gov/pubmed/32493816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00926-20
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