Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells

Increasing attention has been paid to human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) in the field of cancer immunotherapy. We have previously demonstrated that a novel bisphosphonate prodrug, tetrakis-pivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1-bisphosphonate (PTA...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Okuno, Daisuke, Sugiura, Yuki, Sakamoto, Noriho, Tagod, Mohammed S. O., Iwasaki, Masashi, Noda, Shuto, Tamura, Akihiro, Senju, Hiroaki, Umeyama, Yasuhiro, Yamaguchi, Hiroyuki, Suematsu, Makoto, Morita, Craig T., Tanaka, Yoshimasa, Mukae, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385076/
https://ncbi.nlm.nih.gov/pubmed/32793196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01405
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