Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels

Parkin (PRKN) is a ubiquitin E3 ligase that catalyzes the ubiquitination of several proteins. Mutations in the human Parkin gene, PRKN, leads to degeneration of dopaminergic (DA) neurons, resulting in autosomal recessive early-onset parkinsonism and the loss of PRKN function is linked to sporadic Pa...

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Foilsithe in:Biochem Pharmacol
Main Authors: González-Barbosa, Emmanuel, García-Aguilar, Rosario, Vega, Libia, Cabañas-Cortés, María Asunción, Gonzalez, Frank J., Segovia, José, Morales-Lázaro, Sara L., Cisneros, Bulmaro, Elizondo, Guillermo
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376371/
https://ncbi.nlm.nih.gov/pubmed/31404530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.08.002
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