Is there a role for rechallenge and reintroduction of anti-EGFR plus chemotherapy in later lines of therapy for metastatic colorectal carcinoma? A retrospective analysis

BACKGROUND: Mechanisms of resistance have been described during disease progression (PD) for patients under treatment with anti-EGFR plus chemotherapy (CT). The aim of our study was to evaluate efficacy of anti-EGFR rechallenge (ReCH) and reintroduction (ReIn) in metastatic colorectal cancer (mCRC)....

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Опубликовано в: :Ecancermedicalscience
Главные авторы: Karani, Amanda, Felismino, Tiago Cordeiro, Diniz, Lara, Macedo, Mariana Petaccia, Silva, Virgilio Souza e, Mello, Celso Abdon
Формат: Artigo
Язык:Inglês
Опубликовано: Cancer Intelligence 2020
Предметы:
Clinical Study
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373642/
https://ncbi.nlm.nih.gov/pubmed/32728385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3332/ecancer.2020.1069
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