TRAF3 acts as a checkpoint of B cell receptor signaling to control antibody class switch recombination and anergy

B cell receptor (BCR) recognizes foreign antigens to initiate humoral immunity that needs isotype-switched antibodies generated via class switch recombination (CSR); however, stimulating BCR in the absence of co-stimulation (e.g., CD40) does not induce CSR, thus, it remains elusive whether and how t...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Chen, Zhangguo, Krinsky, Alexandra, Woolaver, Rachel A., Wang, Xiaoguang, Chen, Samantha M.Y., Popolizio, Vince, Xie, Ping, Wang, Jing H
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369235/
https://ncbi.nlm.nih.gov/pubmed/32591397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000322
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