Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice

Genetic alterations of tumor suppressor genes (TSGs) are frequently observed to have cumulative or cooperative tumorigenic effects. We examined whether the TSGs Rb1, Trp53, Pten and Men1 have cooperative effects in suppressing neuroendocrine tumors (NETs) in mice. We generated pairwise homozygous de...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Xu, Eugenia Y., Vosburgh, Evan, Wong, Chung, Tang, Laura H., Notterman, Daniel A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2020
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367653/
https://ncbi.nlm.nih.gov/pubmed/32733644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27660
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