Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice

Genetic alterations of tumor suppressor genes (TSGs) are frequently observed to have cumulative or cooperative tumorigenic effects. We examined whether the TSGs Rb1, Trp53, Pten and Men1 have cooperative effects in suppressing neuroendocrine tumors (NETs) in mice. We generated pairwise homozygous de...

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Gepubliceerd in:Oncotarget
Hoofdauteurs: Xu, Eugenia Y., Vosburgh, Evan, Wong, Chung, Tang, Laura H., Notterman, Daniel A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2020
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367653/
https://ncbi.nlm.nih.gov/pubmed/32733644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27660
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