Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice

Genetic alterations of tumor suppressor genes (TSGs) are frequently observed to have cumulative or cooperative tumorigenic effects. We examined whether the TSGs Rb1, Trp53, Pten and Men1 have cooperative effects in suppressing neuroendocrine tumors (NETs) in mice. We generated pairwise homozygous de...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Xu, Eugenia Y., Vosburgh, Evan, Wong, Chung, Tang, Laura H., Notterman, Daniel A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2020
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367653/
https://ncbi.nlm.nih.gov/pubmed/32733644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27660
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