Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model

Dysregulation of histone demethylase Jumonji-C domain-containing protein 5 (JMJD5) has been identified as a great effect on tumorigenesis. Silibinin is a commonly used anti-hepatotoxic drug and exhibits anticancer effect in various cancers. However, the antitumor mechanism between silibinin and JMJD...

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Udgivet i:PLoS One
Main Authors: Yang, Cheng-Yu, Tsao, Chang-Huei, Hsieh, Cheng-Chih, Lin, Chih-Kung, Lin, Chun-Shu, Li, Yu-Hsuan, Chang, Wei-Chin, Cheng, Jen-Chen, Lin, Gu-Jiun, Sytwu, Huey-Kang, Wang, Yin-Lai, Chen, Yuan-Wu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367477/
https://ncbi.nlm.nih.gov/pubmed/32678829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0236101
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