Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion

BACKGROUND: Indoleamine 2,3-dioxygenase (IDO), the first step in the kynurenine pathway (KP), is upregulated in some cancers and represents an attractive therapeutic target given its role in tumour immune evasion. However, the recent failure of an IDO inhibitor in a late phase trial raises questions...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Hornigold, Nick, Dunn, Karen R., Craven, Rachel A., Zougman, Alexandre, Trainor, Sebastian, Shreeve, Rebecca, Brown, Joanne, Sewell, Helen, Shires, Michael, Knowles, Margaret, Fukuwatari, Tsutomu, Maher, Eamonn R., Burns, Julie, Bhattarai, Selina, Menon, Mini, Brazma, Alvis, Scelo, Ghislaine, Feulner, Lara, Riazalhosseini, Yasser, Lathrop, Mark, Harris, Adrian, Selby, Peter J., Banks, Rosamonde E., Vasudev, Naveen S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341846/
https://ncbi.nlm.nih.gov/pubmed/32390008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0874-y
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