Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of (99m)Tc-Tricarbonyl-Based Radiopharmaceuticals

The organometallic technetium-99m tricarbonyl core, [(99m)Tc][Tc(CO)(3)(H(2)O)(3)](+), is a versatile precursor for the development of radiotracers for single photon emission computed tomography (SPECT). A drawback of the (99m)Tc-tricarbonyl core is its lipophilicity, which can influence the pharmac...

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Udgivet i:Molecules
Main Authors: Giammei, Carolina, Balber, Theresa, Benčurová, Katarina, Cardinale, Jens, Berroterán-Infante, Neydher, Brandt, Marie, Jouini, Nedra, Hacker, Marcus, Mitterhauser, Markus, Mindt, Thomas L.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321340/
https://ncbi.nlm.nih.gov/pubmed/32527027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25112680
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