Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice

Epigallocatechin-3-gallate (EGCG) is a candidate therapeutic for Down syndrome (DS) phenotypes based on in vitro inhibition of DYRK1A, a triplicated gene product of Trisomy 21 (Ts21). Consumption of green tea extracts containing EGCG improved some cognitive and behavioral outcomes in DS mouse models...

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Vydáno v:Sci Rep
Hlavní autoři: Goodlett, Charles R., Stringer, Megan, LaCombe, Jonathan, Patel, Roshni, Wallace, Joseph M., Roper, Randall J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319987/
https://ncbi.nlm.nih.gov/pubmed/32591597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67133-z
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