Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia

We previously demonstrated that hexokinase II (HK2) dissociation from mitochondria during cardiac ischemia correlates with cytochrome c (cyt-c) loss, oxidative stress and subsequent reperfusion injury. However, whether HK2 release is the primary signal mediating this ischemia-induced mitochondrial d...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pereira, Gonçalo C., Lee, Laura, Rawlings, Nadiia, Ouwendijk, Joke, Parker, Joanne E., Andrienko, Tatyana N., Henley, Jeremy M., Halestrap, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7313731/
https://ncbi.nlm.nih.gov/pubmed/32579577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234653
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